Introduction: Understanding Depression and Treatment Options
Depression is a complex mental health condition that affects millions of people worldwide, across ages, genders, and cultures. It can show up as ongoing sadness, a loss of interest in things you used to enjoy, low energy, and trouble concentrating. For many people, it also affects the body, causing appetite changes, sleep problems, or unexplained aches and pains. Because depression can affect nearly every part of daily life, timely and effective treatment matters. It helps reduce symptoms and supports overall well-being and quality of life.
For decades, traditional antidepressants like SSRIs and SNRIs have been a common first step in depression treatment. These medications affect brain chemicals called neurotransmitters, mainly serotonin and norepinephrine, which help regulate mood. Many clients do benefit from these medications. At the same time, many people worry about side effects. They may also fear the trial-and-error process of finding the right treatment. Others feel frustrated by the long wait for results. Some people have treatment-resistant depression. This means symptoms continue even after trying traditional approaches.
In recent years, ketamine therapy has gained attention as another treatment option. It can be an alternative to antidepressants or used alongside them. It may help clients who have not found enough relief with standard approaches. Ketamine works differently than SSRIs and SNRIs. Research suggests it may help some people feel better faster than traditional medications. Ketamine is typically provided in carefully controlled, low dose protocols with clinical supervision.
Clinical research continues to explore where ketamine fits best in depression care and who is most likely to benefit. For clients who feel stuck or discouraged, or who want more options, this growing treatment area may feel like a new doorway. It is worth discussing with a qualified provider like The Wellness Drip, Inc in West Springfield, MA.
Understanding ketamine therapy vs. antidepressants can help you open a discussion regarding ketamine therapy with your care team. It can also help you choose options that fit your health history, goals, and comfort level. In the next sections, we’ll break down how each approach works and what those differences may mean in real life.
Mechanisms of Action: How Ketamine and Traditional Antidepressants Work
Traditional antidepressants mainly work on a group of brain chemicals called monoamines, especially serotonin and norepinephrine (and sometimes dopamine). SSRIs increase the availability of serotonin by blocking its reabsorption (reuptake) in the brain. SNRIs increase both serotonin and norepinephrine. Older medications, like tricyclic antidepressants (TCAs), affect several neurotransmitters. They can have more side effects because they act more broadly.
One key point: these medications can change neurotransmitter levels quickly. However, many clients do not feel meaningful symptom relief for several weeks. That delay likely relates to slower brain changes. These include shifts in receptor sensitivity and gene expression. These changes take time to develop. For some clients, especially those with treatment-resistant depression, gradual changes may not be enough. In those cases, clinicians may consider other options.
Ketamine therapy works through a different pathway. Instead of focusing on monoamines, ketamine primarily affects the glutamate system. Glutamate is the brain’s most common excitatory neurotransmitter. It supports learning and memory. It also helps brain circuits communicate. Ketamine acts as an antagonist at N-methyl-D-aspartate (NMDA) receptors. This action affects glutamate signaling. It may increase activity at AMPA receptors. These changes relate to synaptic plasticity. Synaptic plasticity is how the brain strengthens and forms connections.
Researchers believe this boost in neuroplasticity may help explain why some clients experience faster symptom improvement with ketamine than with traditional antidepressants. Some clinicians say it may help the brain “re-open” flexibility in mood-related networks. Responses vary by person, and ketamine is not right for everyone.
The table below summarizes key differences in how ketamine therapy and traditional antidepressants work:
| Aspect | Traditional Antidepressants | Ketamine Therapy |
| Primary Target | Monoamine neurotransmitters (serotonin, norepinephrine) | Glutamate system, NMDA receptor antagonist |
| Onset of Symptom Relief | Several weeks | Hours to days (rapid relief) |
| Effect on Neuroplasticity | Indirect, delayed | Directly enhances neuroplasticity |
| Typical Use | First-line treatment for depression | Treatment-resistant cases or adjunctive |
| Administration | Oral daily medication | Low dose, clinically supervised infusions or nasal spray |
| Side Effect Profile | Varies; may include weight gain, sexual dysfunction | Generally well-tolerated under supervision; transient dissociative effects possible |
Scientific evidence continues to examine these differences and what they mean in real-world care. For example, comparisons of antidepressant treatments show ketamine can work faster than SSRIs. It also affects brain pathways in ways that differ from many traditional medications. In addition, clinical guidelines from authoritative psychiatric associations discuss ketamine’s potential role in individualized care plans for clients with treatment-resistant symptoms.
Because ketamine works differently, it may be considered when symptoms haven’t improved with traditional antidepressants. If you are exploring this option, ketamine therapy may be available with expert clinical supervision. Protocols are designed for safety and your individual response.
In summary, when comparing Ketamine Therapy vs. Antidepressants, the biggest difference is _how_ they act in the brain. Traditional medications gradually influence monoamines over time, while ketamine rapidly affects glutamate signaling and neuroplasticity. Understanding these basics can make it easier to discuss next steps with a qualified provider.
After explaining how these therapies work, the next section focuses on everyday concerns. It covers how soon relief may begin. It also describes what the experience can feel like. Finally, it reviews practical considerations to keep in mind.
Speed of Onset: Rapid Relief vs. Gradual Improvement
Traditional antidepressants, including SSRIs and SNRIs, often take time before clients notice clear changes. For many people, it can take about four to eight weeks to feel meaningful improvement, and sometimes longer to reach the full effect. That waiting period can be tough. It is even harder when symptoms feel intense. Daily functioning may be affected. You may also feel exhausted from feeling “stuck.”
Ketamine therapy is often discussed because it may work faster for some clients. Many people report ketamine rapid relief within hours to a few days after a session. Researchers link this faster response to ketamine’s effects on glutamate signaling and neuroplasticity. These processes help the brain adapt and form new connections.
This timing difference can matter most for clients with treatment-resistant depression or sudden, severe symptom flare-ups. When someone has already tried multiple medications without enough relief, the idea of waiting weeks again can feel discouraging. In some cases, faster symptom relief can create a stabilizing window. It can give time to regain footing. It can also help you re-engage in therapy. You can then build a longer-term plan with your care team. (It’s also important to note that response varies, and ketamine isn’t a guaranteed solution.)
Ketamine therapy is typically delivered in low dose protocols under clinical supervision, with monitoring during and after treatment. This structure supports safety and helps providers adjust care based on how each client responds. The Wellness Drip, Inc., in West Springfield, MA, provides evidence-based ketamine therapy. Our services are supportive, structured, and personalized.
Overall, ketamine can work much faster than traditional antidepressants. Traditional antidepressants often take weeks to help. This contrast shows how depression treatment is evolving.
Effectiveness in Treatment-Resistant Depression
Treatment-resistant depression (TRD) means your depression symptoms have not improved enough. This is after trying at least two different antidepressants. Each trial should use the right dose and last long enough. TRD can be deeply frustrating and draining—especially when you’ve been doing “all the right things” and still don’t feel better. It also creates real challenges for clinicians and clients working together to find a plan that finally brings relief.
Traditional antidepressants can still help with TRD. However, success rates often drop after several medication trials. Many clients cycle through medication switches, dose changes, and add-on treatments. This can take time and increase the emotional burden of care.
Ketamine therapy is often discussed for treatment-resistant depression. Research suggests it may help many people. This includes people who do not improve with standard medications. Some research reviews report response rates in the range of 50–70% for TRD in certain settings and study designs. Results vary, and a “response” does not always mean full remission. For many clients, even partial improvement can be a meaningful step forward.
Two common options are IV ketamine infusions and esketamine nasal spray. Esketamine is FDA-approved for treatment-resistant depression. It must be used under specific safety guidelines. Esketamine offers a non-invasive route, while IV infusions allow for precise dosing and close monitoring. In many care models, ketamine treatment is part of a broader plan. It may include psychotherapy, lifestyle support, and regular follow-up. These supports can help maintain progress over time.
| Aspect | Traditional Antidepressants | Ketamine Therapy |
| Response Rate in TRD | Approximately 20-30% | 50-70% |
| Onset of Action | Weeks to months | Hours to days |
| Mechanism | Modulates monoamines (serotonin, norepinephrine) | Modulates glutamate, enhances neuroplasticity |
| Administration | Oral daily dosing | Low dose IV infusions or nasal spray under supervision |
| FDA Approval for TRD | Yes (SSRIs, SNRIs) | Yes (Esketamine nasal spray) |
| Personalized Care | Limited individualized protocols | Tailored dosing and monitoring |
Research from Nature.com highlights ketamine’s rapid and robust impact on depressive symptoms, especially in treatment-resistant clients.
The Wellness Drip, Inc provides comprehensive ketamine therapy for individuals struggling with treatment-resistant depression, offering IV infusions. Clients benefit from evidence-based protocols delivered with compassionate clinical supervision, with an emphasis on safety and individualized planning.
In summary, when comparing ketamine therapy vs. antidepressants for TRD, ketamine often works faster. Research also shows promising response rates. This may help people who did not improve with standard medications. For many clients, this can feel like renewed hope and forward progress. Even so, the journey may still need support and follow-up.
The next section reviews ketamine therapy safety and side effects versus standard antidepressants. It will help you weigh benefits, risks, and monitoring needs.
Side Effects and Safety Profiles
When considering any mental health treatment, it is reasonable to ask, “What are the side effects and how safe is this for me?” Both standard antidepressants and ketamine therapy can help. Each option also has risks and limits.
The best choice depends on your health history and symptoms. It also depends on how your body responds to treatment.
Traditional antidepressants, including SSRIs and SNRIs, are widely used and generally considered safe when prescribed and monitored appropriately. Still, side effects can be a real barrier for some clients. Common concerns include nausea, weight gain, sexual side effects, fatigue, and sleep problems (either insomnia or feeling overly sleepy). Some clients also notice increased anxiety or agitation early on. Less common risks can be more serious. These risks include serotonin syndrome. They can also include withdrawal symptoms after stopping suddenly. Younger people may also have more suicidal thoughts. Close follow-up matters most during medication changes.
Ketamine therapy has a different side effect profile because it works differently in the brain and body. While some clients experience rapid symptom relief, ketamine can cause short-term effects during or shortly after treatment. These may include dissociation (feeling detached or “spacey”), dizziness, nausea, or a mild headache. Ketamine can temporarily raise blood pressure and heart rate. Reputable clinics monitor vital signs during each session. They also screen for certain heart and blood vessel conditions before treatment. In supervised, low-dose settings, these effects are usually short-lived. They are typically manageable with supportive care. Even so, they still deserve careful discussion before you begin.
Long-term safety data for ketamine in mental health care is still emerging. Its use for depression is newer than standard antidepressants. Current evidence suggests that low-dose ketamine, given with clinical supervision, has a favorable safety profile. It does not appear to carry the same risks as frequent high-dose use. It also differs from non-medical use. For example, bladder problems are more linked to heavy, long-term misuse. Even so, most clinical guidelines stress careful screening, correct dosing, and ongoing monitoring. This is especially important for clients who may need maintenance treatment.
To make the comparison easier, here’s a side-by-side overview:
| Aspect | Traditional Antidepressants | Ketamine Therapy |
| Common Side Effects | Nausea, weight gain, sexual dysfunction, insomnia | Dissociation, dizziness, nausea, increased blood pressure |
| Serious Side Effects | Serotonin syndrome, suicidal ideation in youth, withdrawal symptoms | Cardiovascular risks, potential for abuse, transient dissociation |
| Onset of Symptom Relief | Weeks to months | Hours to days |
| Long-Term Safety Data | Extensive, generally safe with monitoring | Emerging, requires ongoing clinical supervision |
| Monitoring Requirements | Routine follow-up, lab tests for some agents | Blood pressure monitoring, mental status checks during sessions |
| Risk Considerations | Risk of drug interactions, adherence challenges | Careful screening for cardiovascular health and substance use history |
This type of comparison can help you and your clinician decide what matters most. It can include speed, side effects, and safety concerns. It can also include how closely treatment should be monitored. For many clients with treatment-resistant symptoms, ketamine therapy may be worth discussing. It can act quickly and is given under structured clinical supervision. For others, standard antidepressants remain a reliable option, especially when side effects stay manageable and benefits grow over time.
Patient Suitability and Personalized Treatment Protocols
Choosing between ketamine therapy and traditional antidepressants isn’t one-size-fits-all. The best option depends on your symptom history. It also depends on your past treatments. Your overall health matters too. Finally, it depends on what feels realistic and comfortable for you. A thoughtful evaluation, and a personalized plan, can make a big difference in both safety and results.
In general, clients who may consider ketamine therapy include those with treatment-resistant depression and chronic pain. This often means symptoms did not improve after at least two antidepressant trials. Ketamine’s different mechanism and faster onset are often part of why it comes up in these conversations. Clients with mild to moderate depression may prefer traditional antidepressants. This is also true for clients who respond well to standard medications. These medicines are widely available. They are easy to take at home. They also have decades of long-term safety and effectiveness data.
Health conditions and personal history also matter. Because ketamine can temporarily raise blood pressure, some clients need extra cardiovascular screening. Others may be advised to choose a different treatment. Because ketamine can cause dissociation and has misuse risk outside medical care, past substance use matters. It should be discussed openly during treatment planning. None of this is meant to be discouraging, it’s about making sure the plan fits you and supports your safety.
At The Wellness Drip, Inc in West Springfield, MA, ketamine therapy protocols are tailored to the individual’s needs. Low dose ketamine is delivered through IV infusion with adjustments based on response and tolerance. Some clients complete an initial series of six infusions over several weeks. Then they transition to maintenance or “booster” sessions spaced farther apart. The schedule depends on their goals and symptom patterns. This flexibility is one of the practical differences in Ketamine vs. Antidepressants, since traditional medications often follow more standardized daily dosing schedules.
Clinical supervision is a key part of ketamine care. Sessions usually include continuous vital sign monitoring, mental status check-ins, and a calm, supportive setting throughout the experience. Many providers also recommend adding psychotherapy. It helps clients process emotions and strengthen coping skills. It also builds long-term support beyond symptom relief. The Wellness Drip, Inc emphasizes this whole-person approach, combining evidence-based protocols with compassionate oversight.
Here’s a quick comparison of suitability and personalization:
| Factor | Ketamine Therapy | Traditional Antidepressants |
| Ideal Candidates | Treatment-resistant clients, moderate to severe symptoms | Mild to moderate depression, first-line treatment |
| Comorbidity Considerations | Cardiovascular screening essential, caution with substance use history | Generally safe with most comorbidities, but watch for drug interactions |
| Dosing Flexibility | Personalized dosing and frequency based on response | Fixed dosing schedules, gradual titration |
| Administration Routes | IV infusion, intranasal spray | Oral tablets, capsules, or liquids |
| Clinical Supervision | Required during and after administration | Routine outpatient follow-up |
| Integration with Psychotherapy | Strongly recommended for best outcomes | Often combined but not always emphasized |
Ultimately, the “right” approach matches your needs, medical profile, and preferences. It also helps to choose a provider who listens and explains options clearly. Personalized, evidence-based protocols, delivered with proper supervision, can help clients feel confident and supported as they move forward.
For detailed guidance on client suitability and treatment options, consult The Wellness Drip, Inc. We are located in West Springfield, MA. We specialize in personalized, compassionate mental health services.
Research supports these considerations, including findings from a study on ketamine infusion for treatment-resistant depression. Further clinical guidelines are detailed in Ketamine Use for Depression.
Clinical Supervision and Monitoring in Ketamine and Antidepressant Treatments
Clinical supervision matters in any depression treatment, whether you’re exploring ketamine therapy or starting a more traditional antidepressant. The goal is the same in both cases. We support your safety. We track how you are doing. We adjust your care based on your real-life experience.
Because ketamine therapy uses a low dose of a psychoactive medication, it requires careful oversight. Trained medical professionals monitor the patient in real time. Mental health professionals also provide close support during treatment. During ketamine infusions or intranasal esketamine sessions, the care team monitors you in real time. They check your vital signs. They assess your comfort. They watch for side effects. This kind of real-time observation helps the team respond quickly if something feels off.
Antidepressant treatment also benefits from consistent clinical follow-up, especially because many antidepressants take time before you may notice meaningful changes. Regular check-ins help your clinician review symptom patterns. They can adjust your dose when needed. You can also discuss side effects that affect daily life. These may include changes in sleep, appetite, weight, sexual functioning, or mood. Ongoing support is especially important if you and your clinician change or stop a medication. Some people have uncomfortable symptoms if antidepressants are stopped too quickly. Many clinicians also screen for suicidal thoughts, especially early in treatment or during medication changes. This is part of standard safety practice.
In a “Ketamine Therapy vs. Antidepressants” comparison, it helps to remember both options use structured safety steps. The steps differ by treatment. Ketamine protocols may include pre-treatment screening (for example, reviewing cardiovascular history and substance use history) and a post-treatment observation period. Antidepressant care may include regular check-ins. Some medications or health conditions may require lab tests. Ongoing mental health evaluations can help identify new or worsening concerns.
Complementary and Integrated Approaches to Depression Treatment
For many people, depression care isn’t an “either/or” choice, it’s a thoughtful combination of tools. Ketamine therapy and traditional antidepressants can work together in one treatment plan. This can help when symptoms feel complex. It can also help when past treatments have not provided enough relief.
Traditional antidepressants often take weeks to build up to their full effect. Ketamine therapy is discussed differently because some clients report faster relief. Researchers also study ketamine’s link to neuroplasticity. Neuroplasticity is the brain’s ability to form new connections. In an integrated care model, clinicians may combine approaches to support short-term symptom relief and long-term stability. This is often considered in treatment-resistant cases, when appropriate.
Many care plans also work best when medication support is paired with psychotherapy and practical lifestyle strategies. Cognitive behavioral therapy (CBT), for example, can help you build skills to manage negative thoughts. It can also help you handle stress and daily triggers. Emerging research suggests ketamine may support neuroplasticity. This may help some people engage more effectively in therapy during a structured treatment window. Responses vary, and research is still refining best practices. Either way, combining therapy with medication support can help address both the biological and emotional sides of depression.
Holistic, client-centered care also looks beyond symptoms on a checklist. It considers your preferences, your history, and what “feeling better” actually means to you. That may include support around nutrition, movement, sleep routines, and stress management—alongside any medication-based treatment. When a care team coordinates these steps, many clients feel more supported, better informed, and more empowered throughout care.
The Wellness Drip, Inc. offers services aligned with this integrated philosophy. It combines evidence-based ketamine therapy with wellness support and expert clinical care. Clients receiving ketamine therapy can expect care that is personalized to their health needs and life circumstances. Additionally, ketamine may help support individuals experiencing symptoms of anxiety and may be used alongside other treatment approaches, such as therapy or prescribed medications, when clinically appropriate. Its use should always be based on an individualized evaluation and the recommendation of a qualified medical provider.
| Aspect | Ketamine Therapy | Traditional Antidepressants | Integrated Approach |
| Onset of Action | Rapid relief, often within hours | Several weeks to months | Immediate relief with sustained support |
| Mechanism | Enhances neuroplasticity, glutamate system | Modulates serotonin, norepinephrine | Combines neurochemical and behavioral changes |
| Monitoring | Clinical supervision during and post-treatment | Regular psychiatric follow-up | Ongoing assessment and adjustment |
| Complementary Therapies | CBT, lifestyle changes | Psychotherapy, lifestyle modifications | Coordinated multimodal care |
| Suitability | Treatment-resistant, rapid symptom relief | First-line for many depression types | Personalized based on client needs |
An integrated depression care approach can feel hopeful, especially if symptoms have lasted a long time. It can also help you find what truly works for you. In the “Ketamine Therapy vs. Antidepressants” discussion, many people feel reassured. They learn they may not need to choose only one option. With a comprehensive plan, clinicians can often support both symptom relief and long-term quality of life.
Conclusion: Making an Informed Choice Between Ketamine Therapy and Traditional Antidepressants
When you compare ketamine therapy and antidepressants, both can help with depression and anxiety. However, they work differently. They also act on different timelines, and they may fit different needs.
Traditional antidepressants, including SSRIs and SNRIs, are widely used. They are supported by many years of research and clinical experience. They generally work gradually by influencing neurotransmitters like serotonin and norepinephrine. For many clients, that steady approach can be helpful over time. At the same time, some people find antidepressants do not provide enough relief. Others feel they work too slowly. Some experience side effects that are difficult to manage.
Ketamine therapy is often considered when rapid symptom relief matters. It may help when depression does not improve with standard treatments. It is usually given in a low dose. Researchers link it to changes in neuroplasticity, which they still study. Because it can affect perception and the body, ketamine is usually given under clinical supervision. Clinics use safety protocols that support comfort and personalized treatment decisions.
Choosing the right approach usually comes down to your full picture, not just a diagnosis. Symptom severity, past treatment history, medical considerations, lifestyle, and personal preferences all matter. Many people value a provider who explains pros and cons in plain language. They answer questions without pressure. They also adjust the plan based on progress. Collaborative decision-making with specialized providers can help you decide what to do next.
The Wellness Drip, Inc in West Springfield, MA can support you in choosing a thoughtful next step.
Depression treatment continues to evolve. Ongoing research is improving ketamine therapy use. It also refines treatment protocols. It may help develop new antidepressant options. If you are looking for answers, it helps to learn the differences. Working with a qualified, compassionate care team can help you move forward with clarity and confidence.
By making informed choices and seeking supportive care, people can explore depression treatments with more clarity and hope. This can support better well-being and quality of life.
Frequently Asked Questions
What is the main difference between ketamine therapy and traditional antidepressants?
Ketamine therapy can work faster for some people. It targets the brain’s glutamate system. Traditional antidepressants more commonly affect serotonin and/or norepinephrine pathways and often take several weeks to build noticeable effects. This timing and mechanism difference is a key reason the “Ketamine Therapy vs. Antidepressants” comparison matters to many clients.
Is ketamine therapy safe for everyone with depression?
Ketamine therapy is generally viewed as safer when it’s provided under appropriate clinical supervision and after a thorough screening. However, it may not be a fit for everyone. Some clinicians may be cautious with a history of uncontrolled high blood pressure, certain psychotic disorders, or substance use concerns. The best next step is a personalized assessment with a qualified provider to review risks, benefits, and alternatives for your situation.
How quickly can I expect to feel better with ketamine therapy compared to antidepressants?
Some clients report noticeable changes within hours to a few days after ketamine treatment, while traditional antidepressants often take several weeks before improvement is felt. That said, response can vary from person to person, and your provider can help set realistic expectations based on your history and goals.
Can ketamine therapy be combined with traditional antidepressants?
In some cases, yes. Ketamine therapy may be used alongside traditional antidepressants, particularly when depression has been difficult to treat. Any combination should be guided and monitored by a qualified clinician to support safety, avoid unwanted interactions, and track how you’re responding over time.
What are the common side effects of ketamine therapy versus traditional antidepressants?
Ketamine therapy may involve side effects during or shortly after treatment, such as dissociation (feeling detached), dizziness, nausea, or temporary increases in blood pressure. Traditional antidepressants can cause side effects like weight changes, sexual side effects, gastrointestinal upset, sleep changes, or fatigue. Because side effects—and how tolerable they feel, can be very individual, it’s worth having a detailed conversation with your provider before starting either option.
Who is a good candidate for ketamine therapy?
Ketamine therapy is often considered for people with treatment-resistant depression (for example, when multiple antidepressants haven’t helped enough) or when rapid symptom relief is a key concern. A clinician can help determine whether it may be appropriate by reviewing your medical history, mental health history, current symptoms, and treatment goals.
How is ketamine therapy administered clinically?
Clinically, ketamine therapy is commonly provided through intravenous (IV) infusion or as a nasal spray under medical supervision. Protocols vary, but dosing and frequency are typically individualized. Monitoring during and after administration helps the care team support safety, comfort, and timely response to side effects.
References
1. “A comparative assessment of the antidepressant efficacy of ketamine …” — nature.com — https://www.nature.com/articles/s41598-025-29642-7
2. “PDF Ketamine Infusion for Treatment Resistant Depression and Severe” — va.gov — https://www.va.gov/formularyadvisor/DOC\_PDF/CRE\_Ketamine\_Infusion\_for\_Treatment\_Resistant\_Depression\_Rev\_Oct\_2025.pdf
3. “PDF The APA Guidelines on Ketamine Use for Depression CME / ABIM” — ketamind.co.za — https://www.ketamind.co.za/wp-content/uploads/2021/06/American-Psychiatric-Association-Guidelines-on-Ketamine-use-for-Depression.pdf
4. “First study to compare ketamine therapies for patients with severe …” — news.harvard.edu — https://news.harvard.edu/gazette/story/2025/09/first-study-to-compare-two-ketamine-therapies-for-patients-with-severe-depression/
5. “PDF Ketamine Therapy for Psychiatric Disorders and Chronic Pain Management” — oregon.gov — https://www.oregon.gov/osbn/Documents/Resource\_AANA\_KetamineTherapyForPsychiatricDisorders\_2024.pdf
6. “Ketamine and esketamine for treating unipolar depression in … – UpToDate” — uptodate.com — https://www.uptodate.com/contents/ketamine-and-esketamine-for-treating-unipolar-depression-in-adults-administration-efficacy-and-adverse-effects
