NAD+ Therapy

• Memory impairment
• lack of focus and concentration
• acceleration of aging process
• Mitochondrial dysfunction and eventual cellular death.
• Chronic fatigue.
• Weak immune system – infections, cancer
• Alcohol and drug addiction
• Muscle weakness and pain – fatty deposition in muscle tissue.
• Increased fat storage in liver and adipose tissue
• Headache, insomnia
• Lack of ambition, apathy
• Mood and anxiety disorder

• Replicates, protects and repairs cells
• Enhances production of neurotransmitters, thus improving memory, concentration and mood
• Efficiently utilize nutrients to produce the energy the cells need to function optimally.
• Detoxification – removing waste especially in the brain that interferes with neurotransmitters.
• Increases NO (Nitric oxide) production – improves blood flow and blood pressure.
• Improves vascular endothelial integrity,
• Reverses insulin resistance and quickly establishes blood glucose regulation.
• It is a powerful antioxidant anti inflammatory agent.
• The brain uses 10 times more NAD for energy
• It is protective for the cells. NAD has important neuroprotective function.
• NAD boosts metabolism and may help to lose weight.
• Prevents decaying of mitochondria which is a key factor in aging.

• NAD fights aging  by restoring youthful function of basic life sustaining processes in every single cell
• NAD is described as a major advance in “systemic anti-aging medicine”
• NAD is necessary for cellular regeneration.
• NAD turns off genes that are responsible for aging.- silences genes for proteins that accelerate aging (through Sirtuins)
• NAD has an important role in DNA repair and telomere maintenance
• Protection of brain cells and is described as a novel neurotransmitter.
• Important Cell signalling function
• Turns on enzymes (Sirtuins) that slows aging
• Restores mitochondrial decay and dysfunction.
• Mitigates oxidative stress.
• Anti inflammatory – Activates enzymes to prevent and correct DNA damage

1. Gomes AP et al: Declining NAD+ induces a Pseudohypoxic State disrupting nuclear mitochondrial commuinication during aging; Cell. 2013 Dec 19; 155(7): 1624-38. doi: 10.1016/j.cell.2013.11.037.

2. Imai et al:NAD+ and Sirtuins in aging and disease. Trends in Cell Biology24.8 (2014): 464-471   

3 Mach, John, et al. “The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+ (H).” Nutrients 2.3 (2010): 319-329.
Ann Neurol. 2017 Dec 28. doi: 10.1002/ana.25127. [Epub ahead of print]

4. Rocha MC et al: Pathological mechanisms underlyingsingle large scale mitochondrial DNA deletions; Ann Neurol 2017 dec 28; doi: 10.1002 ana.25127

5. Srivastava, S: Emerging therapeutic roles for NAD+metabolism in mitochondrial and age-related disorders:Clinical and Translational Medicine 20165:25 July 2016

6. Shetty, Pavan K., Francesca Galeffi, and Dennis A. Turner. “Nicotinamide pre-treatment ameliorates NAD (H) hyperoxidation and improves neuronal function after severe hypoxia.” Neurobiology of disease 62 (2014): 469-478.

7. Verdin, Eric. “NAD+ in aging, metabolism, and neurodegeneration.” Science 350.6265 (2015): 1208-1213.

8. Imal,S, Guarente L: NAD+ and Sirtuins in aging and disease. Trends Cell Biol. 2014 Aug;24(8):464-71. doi: 10.1016/j.tcb.2014.04.002. Epub 2014 Apr 29.  24360282